Table 3 Gene set enrichment analysis results using Ingenuity Pathway Analysis (IPA)

From: Detection of diagnostic and prognostic methylation-based signatures in liquid biopsy specimens from patients with meningiomas

Term

Geneset

# Of genes

p-value(s): UL, LL

Diseases & Disorders

CNS tumor related

Tissue

38

4.6e−05, 0.006

Serum

26

0.0028, 0.0155

Cancer

Serum

36

0.0012, 0.0175

Tumor development

Tissue

36

7.6e−05, 0.0012

Meningioma-related

Serum

5

1.47e−04, 0.011

MN-1 related

Tissue

1

0.0135

Molecular and cellular functions

Immune Response

Serum

21

4.85e−04, 0.0178

Tissue

1

0.00678

Cell growth/proliferation

Tissue

19

2.32e−04, 0.0284

Serum

9

5.47e−04, 0.0145

Cellular movement

Tissue

17

5.31e−04, 0.0269

Serum

14

0.0047, 0.0179

Cell assembly

Tissue

15

1.74e−04, 0.0282

Serum

5

0.0011, 0.0163

Cell death

Tissue

15

0.0034, 0.0227

Serum

12

0.0011, 0.0145

Embryonic development

Tissue

13

0.0022, 0.0132

Cell cycle

Serum

13

0.0018, 0.0163

Tissue

7

1.26e−04, 0.0285

CNS development

Serum

11

0.0017, 0.0018

Cell-to-cell signaling

Tissue

10

0.0017, 0.0269

Serum

10

4.56e−04, 0.0163

Cell function

Serum

6

0.0018, 0.0181

Cell-mediated immune response

Tissue

3

0.0034, 0.0285

Cell development

Serum

3

0.0012, 0.0018

  1. Most relevant disease and biofunctions predicted by Ingenuity Pathway Analysis (IPA) to be regulated by mRNA expression profiles of high-risk hypermitotic meningioma samples (p-values: right-tailed Fisher’s Exact Test).
  2. MN-1 menin-1, mRNA messenger RNA, IPA Ingenuity Pathway Analysis, UL Upper Limit, LL Lower Limit.