Fig. 2: Rod photoreceptors of iCre/Tctn1^flox mice undergo progressive degeneration.

a Semi-thin retinal plastic sections from iCre/Tctn1^het and iCre/Tctn1^flox mice at 1, 3, and 6 month time points show the progressive loss of rods in iCre/Tctn1^flox mice. Scale bars, 50 µm. Abbreviation: retinal pigment epithelium (RPE). Spider diagrams representing the number of nuclei present in the ONL of iCre/Tctn1^het and iCre/Tctn1^flox at 500 µm intervals from inferior to superior. A minimum of n = 3 independent animals were analyzed for each genotype at each time point. Error bars indicate S.D. b Representative ERG traces at 1, 3, and 6 months from dark-adapted iCre/Tctn1^het and iCre/Tctn1^flox mice in response to full-field flashes of 0.01, 0.1, 1.0 10, and 32 cd*s/m² (top). The averaged dark-adapted a-wave (middle) and b-wave (bottom) amplitudes for each genotype at each time point are plotted and the a-wave responses are fitted using a single hyperbolic function (middle). n = 3 (1 month) or n = 4 (3 and 6 month) independent animals were analyzed for each genotype. Error bars indicate S.D. Source data are provided as a Source Data file.