Fig. 4: Differentially expressed genes in VM from opioid users: Comparison of whole-tissue and cell-specific data. | Nature Communications

Fig. 4: Differentially expressed genes in VM from opioid users: Comparison of whole-tissue and cell-specific data.

From: Single nucleus transcriptomics of ventral midbrain identifies glial activation associated with chronic opioid use disorder

Fig. 4

Forest plots of selected DEGs (FDR P < 0.1) in opioid overdose VM, comparing (x axis log fold change compared to control) previous VM bulk tissue RNA-seq10 to cell-type specific profilings in the current study. Bars represent 95% confidence interval (LFC + /−1.96 S.E.). * bold font marks P value from DESeq2 (Wald test following chi-squared distribution with 1 degree of freedom), FDR (Benjamini–Hochberg) P < 0.1. See also Fig. S8. N = 95 samples (brain donors). Source data are provided as a Source Data file.

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