Fig. 2: Synthetic approach to N-CNS.

Reagents and conditions: (i) M1 (1.0 equiv.), M2 (1.0 equiv.), K₂CO₃ (10 equiv.), Aliquat 336 (5 mol%), Pd(PPh₃)₄ (10 mol%), Ar, toluene/H₂O (v/v, 5:1), 110 °C, 60 h; (ii) P1 (1.0 equiv.), DDQ (16 equiv.), TfOH, Ar, anhydrous CH₂Cl₂, 0 °C, 24 h.