Fig. 10: PZP cells transformed with Ras and SV40-T/t antigens are tumorigenic. | Nature Communications

Fig. 10: PZP cells transformed with Ras and SV40-T/t antigens are tumorigenic.

From: Stromal heterogeneity may explain increased incidence of metaplastic breast cancer in women of African descent

Fig. 10

a CD49f and EpCAM staining patterns of immortalized and transformed PZP (KTB32, KTB40 and KTB42) cell lines. CD49f+/EpCAM−, CD49f+/EpCAM+ and CD49f ̶/EpCAM+ cells correspond to stem/basal, progenitor and differentiated cells, respectively (n = 3). b PROCR and EpCAM staining patterns of immortalized and transformed PZP (KTB32, KTB40, and KTB42) cell lines (n = 3). c CD90 and PROCR staining patterns of immortalized and transformed PZP (KTB32, KTB40, and KTB42) cell lines (n = 3). d IHC analyses of luminal markers ERα, GATA3 and FOXA1 in tumors developed from KTB42-HRasG12V transformed cells (n = 5). e IHC analyses of luminal markers ERα, GATA3 and FOXA1 in tumors developed from the KTB42-HRasG12V + SV40-T/t antigen transformed cells (n = 5). f Tumor developed from KTB42-HRasG12V transformed cells did not show lung metastasis (n = 5). g Tumor developed from KTB42-HRasG12V + SV40-T/t antigen transformed cells did not show lung metastasis (n = 5). H&E staining shows the type of tumors. h Schematic view of study findings.

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