Table 1 Summary of Phe-rich and Phe-low protein expression studies in evaluated cell models and human cerebellum post-mortem tissue

From: Phenylalanine-tRNA aminoacylation is compromised by ALS/FTD-associated C9orf72 C4G2 repeat RNA

 

HEK293 FARSA KD

Differentiated FARS A KD NSC-34

Lymphoblastoid cell lines

Human cerebellum

TSPAN5

↓*

n.s.

↓*

↓***

GOLT1B

↓*

↓*

↓*

n.d.

ALG10B

↓*

↓**

↓*

↓*

PXMP2

↓*

↓*

↓***

n.s.

GAPDH

n.s.

n.s.

n.s.

↓***

LAMINB1

n.s.

n.s.

n.s.

n.s.

  1. Reduction in protein expression (densiometric signal on WB) is indicated with downward arrow. Statistical significance is labeled as *p < 0.05, **p < 0.01, ***p < 0.001. n.s. represent non-significant results and n.d. not determined. Source data are provided as a Source data file.
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