Fig. 4: Comparisons between DNA-PKcs released and chromatin-bound fragments in the absence of DNA-PKcs inhibition. | Nature Communications

Fig. 4: Comparisons between DNA-PKcs released and chromatin-bound fragments in the absence of DNA-PKcs inhibition.

From: Genome-wide analysis of DNA-PK-bound MRN cleavage products supports a sequential model of DSB repair pathway choice

Fig. 4: Comparisons between DNA-PKcs released and chromatin-bound fragments in the absence of DNA-PKcs inhibition.

A Recovery of DNA-PKcs pellet-ChIP products at the top 300 AsiSI cutting sites is shown, in the absence or presence of 4-OHT (4 h) as indicated. B Enrichment for DNA-PKcs GLASS-ChIP versus pellet ChIP is shown for the 300 most efficiently cut AsiSI sites, with Pearson correlation coefficient as indicated. C Genome browser views of 2 AsiSI sites showing GLASS-ChIP and DNA-PKcs pellet-ChIP recovery with 4-OHT addition. Insets show higher resolution views. Green marks indicate locations of AsiSI sites. D High-resolution view of one peak showing signal at the center of the AsiSI cut site. Source data are provided as a Source data file.

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