Fig. 1: Physiological role of human OATP1B1 and OATP1B3.
From: Structure of human drug transporters OATP1B1 and OATP1B3
The schematic shows the uptake of endogenous and exogenous substrates from the blood lumen (systemic circulation) via the space of Disse into hepatocytes. Transporters in the basolateral membrane are shown as surfaces (OATP1B1 and OATP1B3) or yellow shapes. The chemical structures of a selection of substrates of OATP1B1 and/or OATP1B3 are shown on the left and are grouped by whether they are endogenous (left column) or exogenous (right column). The chemical structures were prepared using ChemDraw.
