Fig. 2: Evolving phenotype of T cells during disease progression. | Nature Communications

Fig. 2: Evolving phenotype of T cells during disease progression.

From: Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance

Fig. 2

A Transcriptional phenotype of small, medium and large T cell clones in bone marrow aspirates from healthy adults, MGUS/SMM and MM patients. T cells from the 16 clusters were categorized as small (range, 0–≤ 0.01), medium (range, 0.01–≤ 0.1) and large (range, 0.1–≤ 1) based on the percentage of each clonotype within total T cells and were classified according to their abundance in each clone group. Source data are provided as a Source Data file. B Distribution of the 16 T cell clusters among small, medium and large T cell clones in bone marrow aspirates from four healthy adults, eight MGUS/SMM and ten MM patients. P values were calculated using the Kruskal–Wallis test. Source data are provided as a Source Data file.

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