Fig. 1: Sp1 and Sp3 levels were reduced in arteries of hypertensive patients and angiotensin II (Ang II)-induced hypertensive mice. | Nature Communications

Fig. 1: Sp1 and Sp3 levels were reduced in arteries of hypertensive patients and angiotensin II (Ang II)-induced hypertensive mice.

From: Endothelial Sp1/Sp3 are essential to the effect of captopril on blood pressure in male mice

Fig. 1: Sp1 and Sp3 levels were reduced in arteries of hypertensive patients and angiotensin II (Ang II)-induced hypertensive mice.The alternative text for this image may have been generated using AI.

A, B Representative immunofluorescent (IF) staining of A Sp1 and B Sp3 in mesenteric arteries from hypertensive and healthy individuals. CD31 is an endothelial cell marker. Scale bar: 50 μm. C Quantitative data analysis of (A) and (B). n = 5. D, E Representative IF staining of D Sp1 and E Sp3 in aortas from mice treated with saline or Ang II. CD31 is an endothelial cell marker. Scale bar: 50 μm. F Quantitative data analysis of (D) and (E). n = 5. Western blot (WB) analysis of Sp1 and Sp3 in HUVECs treated with G Ang II (10−6 mol/L, 0–36 h); H ET-1 (10−7 mol/L, 0–36 h) and I H2O2 (10−4 mol/L, 0–36 h). n = 6. Data are presented as mean ± SEM. Two-tailed Student unpaired t test for C and F. One-way ANOVA followed by Bonferroni’s post hoc test for (G) to (I).

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