Table 1 High succinic acid production by metabolically engineered microorganisms
Microorganism | Titer (g/L) | Yield (g/g glucose equivalent) | Productivity (g/L/h) | Medium | pH/neutralizers | Mode | Working volume (L)/Reactor size (L) | Reference |
|---|---|---|---|---|---|---|---|---|
M. succiniciproducens | 134.25 | 0.82 | 21.3 | CDM with glucose and glycerol | 6.5/ammonia and Mg(OH)2 solutions | Fed-batch | 2.5/6.6 | |
E. coli | 113.95 | 0.91 | 3.25 | Corn stalk hydrolysate supplemented with yeast extract | 6.6–7.0/Mg(OH)2 and NH3·H2O | Fed-batch | 1.2/3.0 | |
C. glutamicum | 134 | 1.1 | 2.53 | NaCl solution with glucose and formate | 6.9/KOH | Fed-batch | 0.45/1.4 | |
Y. lipolytica | 101.4 | 0.37 | 0.70 | YP with glucose | 5.5/unspecified | Fed-batch | Unspecified/1.0 | |
Y. lipolytica | 110.7 | 0.53 | 0.80 | YP with glycerol | No neutralizer; final pH 3.4 | Fed-batch | 1.0/2.5 | |
I. orientalis | 109.5 | 0.65 | 0.54 | SC-URA with glucose and glycerol | 3.0/KOH | Fed-batch | 0.1/0.35 | This study |
I. orientalis | 104.6 | 0.63 | 1.25 | Sugarcane juice | 3.0/KOH | Fed-batch | 0.1/0.35 | This study |
I. orientalis | 63.1 | 0.5 | 0.66 | Sugarcane juice | 3.0/ammonia solution | Batch | 30/75 | This study |
