Fig. 3: Mendelian randomization of proteins associated with CKD progression.
From: Proteomics of CKD progression in the chronic renal insufficiency cohort
Eight proteins were linked to pQTLs that had significant Mendelian randomization associations after correction for multiple tests in at least one GWAS for cross-sectional kidney function (eGFR) or for CKD progression (Rapid3 or CKDi25). HR (95% CI) per log2 of protein are shown, for the outcome of ESRD or 50% decline in eGFR, in CRIC, with adjustment for eGFR. pQTLs were identified in CRIC and in deCODE (deCODE marked with *). The three GWAS used are eGFR (red), Rapid3 (blue), and CKDi25 (green). Mendelian randomization associations are shown as red points (% difference in eGFR), or blue and green points that represent odds ratio. If an association met significance after multiple testing, P value is in bold. All P values are two-sided.
