Fig. 2: TMZ-derived AICA activates AMPK. | Nature Communications

Fig. 2: TMZ-derived AICA activates AMPK.

From: Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas

Fig. 2: TMZ-derived AICA activates AMPK.

Immunoblot analyses were performed with the indicated antibodies. Three biological repeats were repeated independently with similar results. a Cells were treated with the indicated dose of TMZ for 2 h. b Cells were treated with the indicated dose of AICA for 2 h. c Cells were treated with 0.25 mM of AICA for the indicated time course. Source data are provided as a Source Data file.

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