Fig. 7: CPI-induced colitis is mediated by CXCR6 expressing tissue-resident T cells.

a Heatmap of co-stimulatory and co-inhibitory expression from Ifng⁺ expressing CD4⁺ and CD8⁺ T cells in comparison to Ifng^--expressing CD4⁺ and CD8⁺ T cells. b Heatmap of chemokines and gut homing gene expression from Ifng⁺ expressing CD4⁺ and CD8⁺ T cells in comparison to Ifng^--expressing CD4⁺ and CD8⁺ T cells. c Percentage of CD3⁺ α4β7⁺ in the colon and mesenteric lymph node (mLN), d colon mass and e number of Gr-1^hi neutrophils in wildtype female 6-week-old CPI colitis mice treated with an isotype control (n = 8) or anti-α4β7 depleting antibody (n = 8). f Number of CD4⁺ and CD8⁺ T cells from the colonic lamina propria and g intraepithelial layer of untreated wildtype female 6-week-old Balb/C mice (Control: n = 10) and CPI + FMT (CPI colitis: n = 10). For both f, g, a two-tailed Mann–Whitney U Test was used where *P = 0.0172 **P = 0.0039 ***P = 0.0007 and ****P < 0.0001.