Table 2 Spearman correlation coefficients (rS) and corresponding two-sided p values (p) for pre- and post-NACT measurements of tumour burden versus blood biomarkers measured at baseline

From: Integrated radiogenomics models predict response to neoadjuvant chemotherapy in high grade serous ovarian cancer

  

Pre-chemotherapy

  

Oment. vol.

Pelvis/ovaries vol.

LN vol.

Total vol.

Number lesions

Summed diameter

Ascites

Pleural effusion

Baseline TP53 MAF

rS

0.04

0.37

0.26

0.37

0.32

0.48

0.05

0.13

 

p

0.77

0.005

0.06

0.005

0.02

0.0003

0.77

0.36

Baseline CA-125

rS

0.41

0.38

0.21

0.48

0.28

0.45

0.28

0.23

 

p

0.002

0.005

0.13

0.0003

0.04

0.0009

0.04

0.10

  

Post-chemotherapy

  

Oment. vol.

Pelvis/ovaries vol.

LN vol.

Total vol.

Number lesions

Summed diameter

Ascites

Pleural effusion

Baseline TP53 MAF

rS

−0.04

0.30

0.13

0.29

0.19

0.41

0.03

0.13

 

p

0.79

0.03

0.36

0.03

0.17

0.003

0.79

0.36

Baseline CA-125

rS

0.10

0.23

0.10

0.22

0.20

0.32

−0.07

−0.16

 

p

0.50

0.10

0.50

0.11

0.15

0.02

0.63

0.24

  1. p values are adjusted for multiple correction.
  2. Significant correlations (p < 0.05) are highlighted in bold.
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