Fig. 7: Differential gene expression in cells with high centrosome amplification and micronuclei frequencies. | Nature Communications

Fig. 7: Differential gene expression in cells with high centrosome amplification and micronuclei frequencies.

From: Molecular landscape and functional characterization of centrosome amplification in ovarian cancer

Fig. 7: Differential gene expression in cells with high centrosome amplification and micronuclei frequencies.The alternative text for this image may have been generated using AI.

Differential gene expression volcano plots of all genes significantly regulated by (a) CA and (b) MN frequencies (high vs. low; median split). FDR < 0.1 highlighted in lightblue/blue. The top 25 most significantly up- or downregulated genes are labelled. c,d Gene set enrichment analysis (GSEA) of centrosome and micronuclei high vs. low cell lines, showing hallmark pathways for which p < 0.05 and FDR < 0.1. Examples of enrichment score plots for centrosome and micronuclei GSEA pathway results are shown in (e) and (f), respectively. Light blue/blue lines illustrate the running sum for each gene set shown. Maximum and minimum enrichment score (ES) are indicated by orange dotted lines. Leading-edge gene subset is indicated by vertical black lines. Source data are provided as a Source Data file. Gene set enrichment analysis and testing was performed using the fgsea R package.

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