Fig. 8: Genomic characterisation of centrosome amplification and micronuclei.

a Correlation of centrosome amplification (CA) with cell line ploidy. b–d Correlations of cell line tMAD scores with CA frequencies, micronuclei (MN) frequencies and CA × MN (combined) frequencies, respectively. tMAD = trimmed median absolute deviation from copy number neutrality. Note that normal cell lines were excluded from this analysis. e–f Correlations of copy number signature exposures with CA and MN frequencies, respectively. Different signatures are indicated by colours. Intercepts and coefficients (slopes; depicted as dots) and their standard errors of the fixed effect model of ALR-transformed copy number signature data for CA and MN frequencies are shown in (g) and (h). i–j Correlations of genome subclonality estimated from ACN fits with CA and MN frequencies. Results are shown for n = 59 cell lines (for which matching sWGS and imaging data was available). All correlation coefficients were estimated using Spearman’s rank correlations (two-sided). Boxplots show 25th, 50th and 75th centiles; whiskers indicate 75th centile plus 1.5 × inter-quartile range and 25th centile less 1.5 × inter-quartile range. Notches on boxes extend 1.58 × inter-quartile range/sqrt(n) approximating to the 95% confidence interval for comparing medians. . Error bands show 95% confidence intervals. Source data are provided as a Source Data file.