Fig. 9: Cell lines with high centrosome amplification show decreased drug sensitivities.
From: Molecular landscape and functional characterization of centrosome amplification in ovarian cancer
a Ovarian cancer cell line drug-screen overview showing drugs used in our drug sensitivity assay and their respective targets within the cell cycle. b Variation in potency and efficacy of selected drugs a cross all tested ovarian cancer cell lines (n = 14). Colours of boxplots indicate drug targets as shown in panel a. Boxplots show 25th, 50th and 75th centiles; whiskers indicate 75th centile plus 1.5 × inter-quartile range and 25th centile less 1.5 × inter-quartile range. Notches on boxes extend 1.58 × inter-quartile range/sqrt(n) approximating to the 95% confidence interval for comparing medians. c Correlation of centrosome amplification frequencies and drug potency (GR50; top panel) and drug efficacy (GRmax; bottom panel). Spearman’s rank correlations (two-sided) are shown for each drug. Drug agents are colour-coded according to their respective drug target groups. Note that higher GR values correspond to lower potency or efficacy. The signs of GRmax values indicated drug response: GRmax > 0 indicates partial growth inhibition; GRmax = 0 indicates complete cytostasis; GRmax <0 indicates cell death (cytotoxicity). Error bands show 95% confidence intervals. Source data are provided as a Source Data file.
