Fig. 1: Extensive clonal evolution of the TFH response over time. | Nature Communications

Fig. 1: Extensive clonal evolution of the TFH response over time.

From: Continually recruited naïve T cells contribute to the follicular helper and regulatory T cell pools in germinal centers

Fig. 1

A Schematic representation of the experimental setup in (C). B Color-coded indexing for the clonal behaviors between day (d) 7 and d21 post immunization in (C). Conserved TCR clonotypes are represented in green, those found only on d7 in white, novel clones appearing only on d21 in orange, and singles in gray. C Pie charts show clones of TFH cells in each mouse at the indicated time. Segments are proportional to the representation of each clone. Numbers inside the pie charts indicate the number of TCR sequences illustrated. GEO Submission (GSE147182). D Schematic (left) and diagrammatic (right) representations of the experimental setup and the fate labeling systems used in (E). E Graph shows the frequency of tdTomato labeled cells in the TFH or in the naïve T cell compartment on days 21 post immunization and 14 after tamoxifen exposure; n = 10 mice per group. Data are presented as mean value ± SD.

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