Fig. 2: Correlation of fitness between environments to identify cross-stress adaptation and tradeoffs for target mutations. | Nature Communications

Fig. 2: Correlation of fitness between environments to identify cross-stress adaptation and tradeoffs for target mutations.

From: Deep mutational scanning reveals the molecular determinants of RNA polymerase-mediated adaptation and tradeoffs

Fig. 2

a Expected correlation of fitness of variants between environments in the case of cross-environment adaptation (left) or tradeoffs (right). b Correlation of the fitness for target mutations measured in M9 minimal media with glucose to the fitness measured in M9 media (blue spheres, left to right) with glycerol, galactose, glucose, and 0.3 M NaCl, glucose, and 0.6% (v/v) butanol respectively. The Spearman correlation coefficient and the associated p-value are mentioned at the top of each curve. c Correlation of fitness for different variants within the target region measured in M9 minimal media (blue spheres) with glucose with the enrichment of the same variants in the ΔrelAΔspoT strain of Escherichia coli upon plating on M9 minimal media agar with Glucose (see Supplementary Fig. 3 for detailed information). Source data are provided as a Source Data file.

Back to article page