Table 2 Inhibitory concentration (IC) 50, 75 and 90 of 10-1074 in a PBMC-based neutralization assay using the different stocks of splenocytes as donor cells

From: Mucosal application of the broadly neutralizing antibody 10-1074 protects macaques from cell-associated SHIV vaginal exposure

Splenocyte donor

10-1074 bNAb (µg/mL)a

IC50

IC75

IC90

SD01

1.07 ± 0.2

1.33 ± 0.1

1.52 ± 0.2

SD02

0.2 ± 0.01

0.59 ± 0.05

1.1 ± 0.06

SD03

0.18 ± 0.04

0.26 ± 0.12

0.32 ± 0.2

SD03 + SD02

0.42 ± 0.03

0.54 ± 0.01

1.03 ± 0.13

SD03 + SD01

<0.062

0.3 ± 0.11

0.43 ± 0.05

  1. aMean ± standard deviation from three independent experiments.
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