Fig. 4: Performance of coronary artery disease polygenic score in different patient subgroups.
From: Clinical utility of polygenic scores for cardiometabolic disease in Arabs
In the validation dataset, the effect of the coronary artery disease (CAD) polygenic score in various clinical subgroups of patients is evaluated. The association of the score with CAD increased with severity of disease as defined by invasive coronary angiography. Obstructive CAD is defined as luminal stenosis of at least 50% in the left main coronary artery or at least 70% in any other coronary artery. The number of vessels with obstructive CAD indicates an increasing burden/severity of disease and manifested a stronger association with the polygenic score. The association of the polygenic score with CAD was consistent across multiple clinical and demographic subgroups. Obesity was defined as body mass index ≥ 30 kg/m2. The odds ratio was assessed in a logistic regression model with age, sex, array version, and the first 10 principal components of ancestry as covariates. For the age and sex subgroups, we excluded those variables from the covariates. P-values were determined using a two-sided Wald test. The black boxes indicate the adjusted odds ratio. The horizontal lines around the black boxes indicate the 95% confidence intervals.
