Fig. 3: Validation of candidate tissue-specific cfRNAs. | Nature Communications

Fig. 3: Validation of candidate tissue-specific cfRNAs.

From: Release of CD36-associated cell-free mitochondrial DNA and RNA as a hallmark of space environment response

Fig. 3

a Venn diagram comparing the 466 space response DRRs and the two gene lists from the HPA database. Gene names for overlapping parts are listed. b–f Normalized quantification values from bulk plasma cfRNA-seq for the DNM3, C1QL3, AMER2, KRT2, and MUC5B genes with mean values (solid lines) and SEM (error bars) calculated from the same biologically independent samples used for Fig. 1e–j. g–k Visualization of mapped cfRNA-seq reads for the genes shown in panels (b–f). Reads from pre-, in-, and post-flight samples were pooled and loaded to the UCSC Genome Browser with representative Ensemble transcript annotations. l–p Tissue expression profiles for genes in panels b–f were obtained from the GTEx database. The horizontal axis represents the corresponding tissue types listed above the graphs.

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