Fig. 6: The area around the Ca²⁺ binding sites in structures of TG3 with and without bound Ca²⁺.

The C1 domain with Tyr526 is shown in dark green. Ca²⁺ are shown as green spheres and are labelled 1–3, H-bonds are shown as broken lines. a Ca²⁺ binding site 1 and TG3 active site with Ca²⁺ (PDB ID 8OXW). b Ca²⁺ binding site 1 and TG3 active site without Ca²⁺ (PDB ID 8OXY). c Ca²⁺ binding site 3 with Ca²⁺. d Ca²⁺ binding site 3 with comparison between TG3 with and without Ca²⁺ bound. e Ca²⁺ binding site 3 in TG3 without Ca²⁺. f Ca²⁺ binding site 2 with Ca²⁺. g Ca²⁺ binding site 2 with comparison between TG3 with and without Ca²⁺ bound. h Ca²⁺ binding site 2 in TG3 without Ca²⁺.