Fig. 4: 3D volumetric photoacoustic imaging of uterine and fetal responses to vasodilators.
From: In vivo noninvasive systemic myography of acute systemic vasoactivity in female pregnant mice
a uterine artery and (d) fetal vasculature at different time points post-injection. Here, placenta (p), uterine artery (UtA), fetal head (h), umbilical cord (um) and fetal aorta (fa). b–e Scatter plot of maximum increase in photoacoustic signal intensity of uterine artery and fetal vasculature as a measure of blood volume from pre-injection state respectively with mean and standard deviation (G-1, Sildenafil: n = 8 mice/group, PBS: n = 7 mice). A significant increase in the photoacoustic signal intensity of the uterine artery compared with PBS with a p-value of 0.0136 (*) was tested via one-way ANOVA followed by an ad hoc t-test (two-tailed, G-1 vs. PBS p-value 0.0156(*), Sildenafil vs. PBS p-value 0.0103(*)). c–f Time duration for peak response of uterine artery and fetal vasculature due to sildenafil and G-1 respectively with mean and standard deviation (n = 8 mice/group). The color bar represents the normalized photoacoustic signal intensity. Source data are provided as a Source Data file.
