Fig. 1: Structures of CCR5 and CXCR4 homodimer and CCR5–CXCR4 heterodimer.
From: Structural basis of dimerization of chemokine receptors CCR5 and CXCR4
A Binding free energy surface (BFES) of CCR5 homodimerization. B BFES of CXCR4 homodimerization. C BFES of CCR5–CXCR4 heterodimerization. The convergence of the free-energy calculation between bound and unbound states is shown as inset for each system. The atomistic structures of the lowest energy dimeric states for each system are displayed on the right as gray cartoons with the transmembrane helices at the interface colored according to the color code reported at the top of the figure.
