Fig. 5: The binding mode of fenoterol to Organic Cation Transporter 1 favors the (S,S)- stereoisomer.
From: Structural basis of promiscuous substrate transport by Organic Cation Transporter 1
a Fenoterol bound to inward-open OCT1 with hydrogen bonds between the resorcinol group and residues Q241 and Y361. The cryo-EM map contained additional density in the flexible linker of fenoterol that would favor the (S)-hydroxy position over the (R)- isomer. b Comparison of the interaction between (S,S)- and (R,R)-fenoterol to the surface of the C-terminal lobe of OCT1. Only the (S)-hydroxy group pointed towards the hydrophilic pocket. c Summary of the binding interactions of (S,S)-fenoterol to inward-open OCT1.
