Fig. 6: Transcriptomic profiling of tumor tissues derived from KO and KO + NM1 MEFs shows transcriptional rescue upon NM1 overexpression. | Nature Communications

Fig. 6: Transcriptomic profiling of tumor tissues derived from KO and KO + NM1 MEFs shows transcriptional rescue upon NM1 overexpression.

From: Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice

Fig. 6: Transcriptomic profiling of tumor tissues derived from KO and KO + NM1 MEFs shows transcriptional rescue upon NM1 overexpression.The alternative text for this image may have been generated using AI.

a Gene ontology analysis of genes that are found to be upregulated in tumors derived from KO cells in comparison to tumors derived from KO + NM1 cells. The top 10 enriched biological process, cellular component, and KEGG pathway terms are shown in descending order based on their significance. b Gene ontology analysis of genes that are found to be downregulated in tumors derived from KO cells in comparison to tumors derived from KO + NM1 cells. The top 10 enriched biological process, cellular component, and KEGG pathway terms are shown in descending order based on their significance. c Heatmap of most differentially expressed genes (log2FC ≥ 4 for upregulated genes and log2FC ≤ -4 for downregulated genes) between tumors associated with cell cycle and cell division. Heatmap represents the log2-normalized counts for each tumor sample derived either from KO or KO + NM1 cells organized in descending order based on log2 fold change value. d Heatmap of the most differentially expressed genes (log2FC ≥ 2 for upregulated genes and log2FC ≤ -2 for downregulated genes) between tumors associated with DNA damage response and repair. Heatmap represents the log2-normalized counts for each tumor sample derived either from KO or KO + NM1 cells organized in descending order based on log2 fold change value. e Heatmap of differentially expressed genes (log2FC ≥ 1 for upregulated genes and log2FC ≤ -1 for downregulated genes) between tumors associated with Oxidative phosphorylation. Heatmap represents the log2-normalized counts for each tumor sample derived either from KO or KO + NM1 cells organized in descending order based on log2 fold change value. Source data are provided as a Source Data file.

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