Fig. 8: Proposed mechanism of NM1 action in PI3K/Akt/mTOR signaling. | Nature Communications

Fig. 8: Proposed mechanism of NM1 action in PI3K/Akt/mTOR signaling.

From: Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice

Fig. 8: Proposed mechanism of NM1 action in PI3K/Akt/mTOR signaling.The alternative text for this image may have been generated using AI.

We propose that NM1 has a critical function as a regulator of cellular metabolism and it is part of the PI3K/Akt/mTOR pathway. Upon external stimulus, PI3K/Akt/mTOR cascade is activated leading to phosphorylation of several downstream targets activating NM1 which in a positive feedback loop transcriptionally regulates mTOR and the expression of mitochondrial transcription factors TFAM and PGC1α responsible for mitochondrial biogenesis. Created with BioRender.com.

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