Fig. 2: Unbiased classification reveals conserved peptide backbones across HLA allotypes. | Nature Communications

Fig. 2: Unbiased classification reveals conserved peptide backbones across HLA allotypes.

From: HLA3DB: comprehensive annotation of peptide/HLA complexes enables blind structure prediction of T cell epitopes

Fig. 2

a A schematic of the greedy algorithm used to select discrete peptide backbones. b A two-dimensional PCA plot standardized with the sine of the dihedral angles of P4 to P7 explaining 66% of the variance. c Historical analysis of the cumulative number of ∆7 structures (blue) and discrete peptide backbones (red) in HLA3DB as determined iteratively by the greedy algorithm. d The proportion of supertype in each discrete peptide’s set of neighbors. The number of neighbors for each discrete peptide is shown in the right y-axis.

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