Fig. 3: Transcriptomic analyses shows that DNA damage and cell cycle arrest are early effects of radiation. | Nature Communications

Fig. 3: Transcriptomic analyses shows that DNA damage and cell cycle arrest are early effects of radiation.

From: A human lung alveolus-on-a-chip model of acute radiation-induced lung injury

Fig. 3: Transcriptomic analyses shows that DNA damage and cell cycle arrest are early effects of radiation.The alternative text for this image may have been generated using AI.

a Volcano plot of differentially expressed genes (DEGs) of alveolar epithelium, 6 h after radiation exposure, for adjusted p < 0.01. b Volcano plot of differentially expressed genes (DEGs) of endothelium, 6 h after radiation exposure, for adjusted p < 0.01. Adjusted p-values were obtained by applying Bonferroni correction for multiple comparison. c GSEA of Hallmark gene sets on the epithelium showing downregulation of hallmark E2F targets, mitotic spindle, and G2M checkpoints and upregulation of EMT, with q < 0.05. d GSEA of the endothelium showing downregulation of hallmark E2F targets, G2M checkpoints, and mitotic spindle, and upregulation of inflammatory responses. Plots created with Pluto (https://pluto.bio).

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