Table 1 Mouse mutant alleles and strains utilized in genetic epistasis analyses

Pkhd1^LSL

-

or

KO

Pkhd1 KO

https://www.jax.org/strain/019423

Bakeberg et al., 2011 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250208/¹⁷

Pkhd1^Δ3-4

Δ3–4

Hypomorphic allele

https://www.pkd-rrc.org/downloads/pkhd1delta3-4/

Garcia-Gonzalez et al., 2007

https://pubmed.ncbi.nlm.nih.gov/17575307/⁴³

Pkhd1^Δ67

ΔCT

Deletes exon 67 that encodes C-terminal 137 aa.

https://www.pkd-rrc.org/downloads/pkhd1delta67/

Outeda et al., 2017 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005173/¹⁴

Pkhd1^Flox67HA

HA

A triple HA -tag is knocked-in at the C-terminus of FPC.

https://www.pkd-rrc.org/downloads/pkhd1ha/

Outeda et al., 2017 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005173/¹⁴

Pkd1^V

V

Pkd1 GPS mutant, expressing uncleavable PC1^V.

https://www.pkd-rrc.org/downloads/pkd1v-2/

Yu et al., 2007 https://pubmed.ncbi.nlm.nih.gov/18003909/²⁴