Fig. 8: Schematic diagram of the mechanism. | Nature Communications

Fig. 8: Schematic diagram of the mechanism.

From: C-type lectin receptor 2d forms homodimers and heterodimers with TLR2 to negatively regulate IRF5-mediated antifungal immunity

Fig. 8: Schematic diagram of the mechanism.The alternative text for this image may have been generated using AI.

During C. albicans infection, CLEC2D in dendritic cells forms homodimers or heterodimers with TLR2 to recognize β-glucan derived from C. albicans. This process triggers Smurf1-mediated K-48 linked ubiquitin degradation of MyD88, thereby inhibiting the activation of transcription factor IRF5 and subsequent IL-12 production. Created with BioRender.com.

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