Fig. 5: Co-localization of B. malayi genes in Wolbachia+ versus Wolbachia- spots. | Nature Communications

Fig. 5: Co-localization of B. malayi genes in Wolbachia+ versus Wolbachia- spots.

From: Miniature spatial transcriptomics for studying parasite-endosymbiont relationships at the micro scale

Fig. 5: Co-localization of B. malayi genes in Wolbachia+ versus Wolbachia- spots.The alternative text for this image may have been generated using AI.

A UMAP showing spots with presence (Wolbachia + /W + ) or absence (Wolbachia-/W-) of Wolbachia. Dotted lines outline the different clusters from Fig. 2B. B Volcano plot showing the differentially expressed genes in Wolbachia+ versus Wolbachia- spots (green: average log fold change <0.4 and adjusted p value < 0.05, orange: average log fold change > 0.4 and adjusted p-value < 0.05). Differential expression analysis used the Wilcoxon Rank Sum test and adjusted p values (p) were estimated with a two-sided alternative hypothesis. C–D 3D model and 2D images of gene expression in sample BM2 (sections BM2_4 and BM2_9) for two differentially expressed genes, Bma-snx-1 (C) and Bma-ned-8 (D), between Wolbachia + (W + ) and Wolbachia- (W-) spots. Magnification 20x. A: Anterior, P: Posterior, arrow indicates first to last section through the worm.

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