Fig. 4: Apparent observed cohort differences in the detection of Veillonella and Prevotella.
From: The airway microbiota of neonates colonized with asthma-associated pathogenic bacteria
a, b Comparison of COPSAC2010 hypopharyngeal aspirates and COPSAC2000 nasopharyngeal swabs by genus names. Veillonella and Prevotella are highlighted due to their significant association with asthma in COPSAC2010 (dark gray). Gemella, Streptococcus, and Neisseria also contributed to the bacterial asthma score, but were not individually significant after FDR correction (light gray). Different regions were amplified in the two cohorts (COPSAC2000—V3-V4; COPSAC2010—V4), but the bioinformatics and data processing pipeline was identical (DADA2 + AnnotIEM, see methods). c, d Genus abundance values of Veillonella and Prevotella are not associated with persistent wheeze/asthma by age 7 in COPSAC2000. e Veillonella and/or Prevotella presence is not associated with persistent wheeze/asthma by age 7 in COPSAC2000. Their association estimate attenuated after mutual adjustment with the pathogen score, which in contrast did not attenuate. Dots indicate estimates, error bars indicate 95% confidence intervals (CI). N = 285 (COPSAC2000), N = 641 (COPSAC2010). P values are two-sided and not adjusted for multiple comparisons.
