Table 1 Structural similarities among metazoan, fungi and protist pre-snRNA

From: The SMN complex drives structural changes in human snRNAs to enable snRNP assembly

pre-snRNA

Metazoa

Protists*

Fungi**

pre2-u1

0.38

0.58/0.51

0.51/0.52

pre2-u2

0.29

0.44/0.42

0.49/0.43

pre2-u4

0.22

0.48/0.47

0.57/0.57

pre5-u5

0.37

0.46/0.42

0.43/0.45

  1. *Species best distributed across protist taxonomy space/species best distributed across taxonomy space with model organisms.
  2. **Species best distributed across fungi phyla/species best distributed across fungi phyla with model organisms.
  3. Pairwise similarities of best representative suboptimal structures averaged for individual metazoan, protist, and fungi major pre-snRNAs. Note that the less is the number, the higher is the structure similarity, as the similarity was computed using tree edit distances. Longest extra sequences were used to obtain pre-snRNA sequences. Two-sample two-tail t-test compared metazoan and protist similarities for alternative species distribution (see the table comments) with a p-value = 0.0115/0.0180, and metazoan and protist similarities with a p-value = 0.0079/0.0115. These p-values show that metazoan and protist, and metazoan and fungi populations have unequal means, which indicated that if metazoan best representative suboptimal structures showed structure similarity, protist/fungi best representative suboptimal structures should have structure dissimilarity, suggesting the NSS is not evolutionarily conserved in protist and fungi structures.
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