Fig. 4: Competitiveness of Delta B.1.617.2 and Omicron B.1.1.529 in animals naïve to SARS-CoV-2 and with pre-existing immunity. | Nature Communications

Fig. 4: Competitiveness of Delta B.1.617.2 and Omicron B.1.1.529 in animals naïve to SARS-CoV-2 and with pre-existing immunity.

From: Infection- or AZD1222 vaccine-mediated immunity reduces SARS-CoV-2 transmission but increases Omicron competitiveness in hamsters

Fig. 4: Competitiveness of Delta B.1.617.2 and Omicron B.1.1.529 in animals naïve to SARS-CoV-2 and with pre-existing immunity.

a The receptor binding domain of the SARS-CoV-2 spike was sequenced for all sgRNA positive swabs collected at 2, 3, and 5 DPI/DPE, and lungs and nasal turbinates collected on 5 DPI/DPE. Heatmap representing all sgRNA positive swab samples from each individual for each naïve chain and showing the percentage of Delta B.1.617.2 detected. Colors refer to legend on right (D = donor, S = sentinel, NC = naïve control), grey = no sgRNA present in the sample or sequencing unsuccessful. b Heatmap displaying all sgRNA positive samples from each individual for vaccinated or previously infected chains and showing percentage of Delta B.1.617.2 detected. Colors refer to legend on right (D = donor, S = sentinel, NC = naïve control), grey = no sgRNA present in the sample or sequencing unsuccessful. c Overall percentage of Delta B.1.617.2 and Omicron B.1.1.529 in all sgRNA positive samples in each naïve group, separated by tissue type. d Overall percentage of Delta B.1.617.2 and Omicron B.1.1.529 in all sgRNA positive samples in each vaccinated or previously infected group, separated by tissue type. Bar charts depicting mean and 95% CI. Number of sgRNA positive samples over all samples analyzed is indicated on top, individual data points are depicted (dots represent percentage of Omicron B.1.1.529, light purple). Yellow = Delta B.1.617.2, purple = Omicron B.1.1.529. Source data are provided as a Source Data file.

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