Fig. 1: The predicted phase behaviour of the human proteome and AMPs.
From: Targeting nucleic acid phase transitions as a mechanism of action for antimicrobial peptides
Homotypic phase separation propensity (x-axis) and RNA-mediated phase separation propensity (y-axis) for human proteome (a, 20324 proteins; UniProt) and a set of 13170 AMPs (b)40. The colour bar represents the overall phase separation propensity score density. Several proteins (e.g. FUS) known to undergo LLPS are shown as reference points. The diagonal black lines separate regions of amino acid chains with a higher propensity to undergo phase separation in the presence of nucleic acids compared to homotypic phase separation propensity (above the line), while regions below the line represent nucleic acid-mediated phase separation being less favourable than homotypic phase separation. Source data are provided as a Source data file.
