Fig. 3: Tissue specificity of TE-eQTLs.
a Mosaic plot of tissue specificity of TE-eQTLs. b Tissue specificity and distance of TE-eQTL to transcription start site (TSS). The shared TE-eQTLs (black) are closer to the TSS than are the tissue specific TE-eQTLs (red) (two-sided Wilcoxon p < 2.2e−16). c TE-eQTL slopes for the normal specific TE-eQTLs in blue, the tumor specific in red and shared in black. d Boxplot of the absolute value difference of median methylation betas between normal and tumor samples for shared (n = 248) and tumor-specific (n = 675) TE-eQTLs. We observe significant increase in methylation change for tumor-specific TE-eQTLs compared to shared TE-eQTLs between normal and tumor (two-sided Wilcoxon test, p = 2.5e−11). Shared TE-eQTLs box plot values: minima = 1.987e−3; 1st quartile = 9.550e−3; median = 0.025; mean = 0.046; 3rd quartile = 0.062; maxima = 0.274. Tumor-specific TE-eQTLs box plot values: minima = 9.908e−4; 1st quartile = 0.021; median = 0.05; mean = 0.072; 3rd quartile = 0.11; maxima = 0.438. Source data are provided as a Source Data file.
