Fig. 3: Quantification of immune and structural cells in COVID-19 lungs. | Nature Communications

Fig. 3: Quantification of immune and structural cells in COVID-19 lungs.

From: Single cell spatial analysis reveals inflammatory foci of immature neutrophil and CD8 T cells in COVID-19 lungs

Fig. 3: Quantification of immune and structural cells in COVID-19 lungs.The alternative text for this image may have been generated using AI.

a–c Cell abundance plots for immune cells (myeloid and lymphoid cells) and structural cells in lung tissue, adjusted for surface area in COVID lungs categorised into those with histopathology states of alveolitis(ALV) (n = 4 patients, 10 ROIs), diffuse alveolar damage (DAD) (n = 4 patients, 8 ROIs) and organising pneumonia (OP) (n = 4 patients, 8 ROIs), compared to healthy control (n = 2 individuals, 4 ROIs). Line in figure represents median. See Supplementary Table 4 for extended phenotypic description for all cell types and clusters. Source data are provided in the Source Data File. d Heatmap of fold change (FC) difference in abundance of cell types for COVID-19 samples (ALV, DAD and OP) vs healthy controls (HC) depicted in (a). Asterisks show those with significant differences - adjusted p values are *p < 0.05 **p < 0.01 ***p < 0.001, calculated using code from the diffcyt R package (version 1.8.8) with the option testDA_edgeR; two-sided analysis employed, and multiple comparisons adjusted using Benjamini-Hochberg method. Arrow refers to immune cells that showed progressive increase in abundance with progression histopathology states from ALV to OP.

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