Table 1 Pathway-level analysis to compare the choline metabolites in Atp8b1IEC-KO mice (line #12) and the littermate Atp8b1flox/flox mice

From: Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis

 

Integrated P value

Mean difference

Mean t statistics

IEC

0.11

0.56

1.47

Plasma

1.65e−04

−0.27

2.06

Liver

1.28e−05

−0.63

3.16

  1. The metabolome data obtained in Fig. 4 were used for this analysis. Each value was calculated by the generally applicable gene set enrichment (GAGE) method58. Briefly, metabolites in the choline pathway and overall metabolites were subjected to Welch’s t test, comparing all sample combinations of Atp8b1IEC-KO mice (line #12) and the littermate Atp8b1flox/flox mice. Negative log-sum values of resultant P values were adjusted based on control group dependencies, and the integrated P value was computed on a Gamma distribution with K degrees of freedom and a scale of 1.0, where K represents the number of samples of Atp8b1IEC-KO mice (line #12).
  2. IEC intestinal epithelial cells.
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