Fig. 2: DC-specific Zeb1-deficient mice are resistant to Listeria infection.
a Survival of WT and Zeb1-dcKO mice infected intravenously (i.v.) with 1 × 106 CFU of L. monocytogenes (n = 10). b Listeria CFUs per spleen and liver of WT and Zeb1-dcKO mice at day 2 after i.v. infection with 2.5 × 104 CFU of L. monocytogenes (n = 5). c Histopathology (H&E) of spleen and liver from WT and Zeb1-dcKO mice at day 2 after i.v. infection with 2.5 × 104 CFU of L. monocytogenes (scale bars: 100 μm). Numbers of lesions in the sections were enumerated and shown at the bottom. d ELISA of cytokines secreted to serum of WT and Zeb1-dcKO mice at indicated time points after i.v. infection with 1 × 106 CFU of L. monocytogenes (WT, n = 5; Zeb1-dcKO, n = 7; For IL-10, n = 4). Each symbol represents an individual mouse, small horizontal lines indicate the mean (± s.d.). Data are representative of three independent experiments. Data are presented as mean ± s.d. nd: not detected. Statistical analysis was performed using two-tailed unpaired Student’s t-test (b) or two-way ANOVA with Sidak’s multiple comparisons test (d), or log-rank (Mantel–Cox) test of survival curve (a). Source data are provided as a Source Data file.
