Fig. 1: Study approach. | Nature Communications

Fig. 1: Study approach.

From: CD8+ T cells control SIV infection using both cytolytic effects and non-cytolytic suppression of virus production

Fig. 1

a Experimental design: 20 rhesus macaques (RMs) were infected with SIVmac251. At 56 days post infection the CD8+ cells depleting antibody, M-T807R1, was infused in 12 RMs, with a second infusion three weeks later. Two days after the first CD8+ cell depletion, raltegravir (RAL) monotherapy was initiated in 8/12 RMs (CD8 depletion group plus RAL Tx group), with the remaining 4/12 serving as untreated controls (CD8 depletion group). An additional 8 RMs without CD8+ T cell depletion were also treated with RAL monotherapy under the same conditions (RAL Tx group). b We developed mathematical models to analyze plasma viral load and blood Ki67+ CD4+ T cell count from the time of first M-T807R1 administration to the end of RAL Tx.

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