Fig. 4: The effect of M-T807R1 administration and RAL monotherapy on plasma viral load.

a CD8 depletion group (n = 4); b CD8 depletion plus RAL Tx group (n = 8); c RAL Tx group (n = 8). Vertical dashed lines represent the times of M-T807R1 administration and shaded regions represent RAL administration. d Distributions of the plasma median viral load before (after viral load reached steady state) the first M-T807R1 administration, and the maximum and minimum viral loads after (CD8 depletion group, n = 4; CD8 depletion plus RAL Tx group, n = 8; RAL Tx group, n = 8). e Distribution of the change in the log₁₀ plasma viral load from the time before the first M-T807R1 administration (day 0 in panels a, b, c) to the maximum value after that time. f Distribution of the maximum decay in the log₁₀ plasma viral load during the time of RAL monotherapy relative to the start of RAL. In (e) and (f), we used the Mann–Whitney test (two-sided) to compare the CD8 depletion plus RAL Tx group with the RAL Tx group (n = 8 for each group). In all the panels, blue for CD8 depletion group; red for CD8 depletion plus RAL Tx group; and gold for RAL Tx group; with different symbols indicating different macaques. In (d) to (f), individual data points and box plots are presented. Box plots represent the 25th and 75th percentiles (bottom and top edge of the box), the median (line across the box), whiskers extending from the edge of the box to the smallest (bottom) or largest (top) value no further than 1.5 times the interquartile range from the box’s edges, and extreme values beyond that shown as crosses.