Fig. 3: Combinatorial screening of the direct α-asymmetric alkylation of aldehydes merged with photoredox catalysis and organocatalysis. | Nature Communications

Fig. 3: Combinatorial screening of the direct α-asymmetric alkylation of aldehydes merged with photoredox catalysis and organocatalysis.

From: Ultra-high-throughput mapping of the chemical space of asymmetric catalysis enables accelerated reaction discovery

Fig. 3: Combinatorial screening of the direct α-asymmetric alkylation of aldehydes merged with photoredox catalysis and organocatalysis.

a Chemical reaction formula and the structures/names of the 10 bromoacetophenone substrates, 11 organocatalysts, and 13 photocatalysts. b Heatmap visualization of the ee values of the 1430 reactions determined by the IM-MS. c Eleven of selected extracted ion mobilograms (EIMs) for the screened reactions with substrate S2, photocatalyst P2 and different organocatalysts.

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