Fig. 3: Effect of Lcn2 deficiency on CL316, 243-induced changes in cardiolipin content in BAT. | Nature Communications

Fig. 3: Effect of Lcn2 deficiency on CL316, 243-induced changes in cardiolipin content in BAT.

From: Lipocalin 2 regulates mitochondrial phospholipidome remodeling, dynamics, and function in brown adipose tissue in male mice

Fig. 3

WT and Lcn2 KO mice at 8–10 weeks of age were treated with either saline or CL316, 243 (0.5 mg/kg BW) via i.p. injection once a day for 14 days. Global analysis of total cardiolipins (a), PCA (b), and hierarchical clustering (c). CL316, 243-induced changes in the content of individual cardiolipins (d-u). Results are presented as mean ± SEM. Student’s t-test was performed to test differences between two independent groups. All tests were two-sided. n = 4 (saline-treated WT and Lcn2 KO mice), n = 5 (CL316, 243-treated WT and Lcn2 KO mice). Source data are provided as a Source data file.

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