Fig. 7: Micro-ecological module-based breast cancer ecotypes associated with molecular features and patient prognosis. | Nature Communications

Fig. 7: Micro-ecological module-based breast cancer ecotypes associated with molecular features and patient prognosis.

From: Single-cell morphological and topological atlas reveals the ecosystem diversity of human breast cancer

Fig. 7: Micro-ecological module-based breast cancer ecotypes associated with molecular features and patient prognosis.The alternative text for this image may have been generated using AI.

a Hierarchical clustering of micro-ecological module composition identifies four breast cancer ecotypes. b Gene sets enriched in the samples of each ecotype revealed by gene sets enrichment analysis. The NES and P value output by GSEA are presented. c Association between breast cancer ecotypes and tumor T category, N category, grade and IHC subtypes. P values are calculated using the chi-square test. d Kaplan-Meier curves of recurrence-free survival according to the breast cancer ecotypes. e Multivariate Cox regression analysis reveals breast cancer ecotype as an independent prognostic factor of recurrence-free survival (n = 537). Squares and whiskers represent point estimates and the 95% confidence interval of hazard ratios. RFS recurrence-free survival, IHC immunohistochemistry, NES normalized enrichment score.

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