Fig. 8: Summary of the present study.

Left panel: The analytic workflow of generating and using sc-MTOP data to dissect the ecosystem diversity of human breast cancer at multiple levels. Right panel: The ecosystem features with therapeutic and prognostic implications. Created with BioRender.com. sc-MTOP single-cell morphological and topological profiling, MEM micro-ecological module, AIC score aggregated inflammatory cell abundance score, MITH morphological intratumor heterogeneity.