Fig. 6: Knockdown of TG2 abolishes the inhibitory effect of sTREM2 on tau phosphorylation. | Nature Communications

Fig. 6: Knockdown of TG2 abolishes the inhibitory effect of sTREM2 on tau phosphorylation.

From: Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer’s disease

Fig. 6

a p-Tau S202/T205 immunostaining and quantification of 7-month-old mice injected with sh-TG2 and sTREM2. Scale bar, 250 μm (mean ± s.e.m.; two-way ANOVA, n = 6 mice per group). b Western blots showing the phosphorylation of tau, GSK3β, and RhoA (mean ± s.e.m.; two-way ANOVA, n = 8 mice per group). c Electron microscopy of synapses in the hippocampus (left). Stars indicate synapses. Scale bar, 1 μm. Quantification of synaptic density (right) (mean ± s.e.m.; two-way ANOVA, n = 6 mice per group). *P < 0.05, **P < 0.01, ***P < 0.001.

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