Fig. 7: A short peptide of sTREM2 suppresses tau hyperphosphorylation in vitro. | Nature Communications

Fig. 7: A short peptide of sTREM2 suppresses tau hyperphosphorylation in vitro.

From: Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer’s disease

Fig. 7

a Schematic illustration of sTREM2 fragments. b GST pull-down assay showing the interaction between GST-sTREM2 fragments and His-TG2. n = 4 independent experiments. c, d Western blots showing the phosphorylation of tau and GSK3β in HEK293-Tau cells treated with different sTREM2 peptides (10 μM) for 24 h (mean ± s.e.m.; one-way ANOVA, n = 4 independent experiments; compared with the control group). e p-Tau S202 immunostaining of HEK293-Tau cells treated with different sTREM2 peptides (10 μM) for 24 h. Scale bars, 15 μm. f Quantification of p-tau S202 (mean ± s.e.m.; one-way ANOVA, n = 7 independent experiments; compared with the control group). *P < 0.05, **P < 0.01, ***P < 0.001.

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